HCID 22314545、化合物 → 1-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

HRID 966095ノート

反応式

HRID 966095 の反応式
[CH3:1][C:2]([NH:6][CH2:7][C:8]([C:10]1[CH:30]=[CH:29][C:13]2[O:14]C(C3C=CC=CC=3)(C3C=CC=CC=3)[O:16][C:12]=2[C:11]=1[O:31][CH3:32])=[O:9])([CH3:5])[CH2:3][CH3:4]>Cl>[OH:16][C:12]1[C:11]([O:31][CH3:32])=[C:10]([C:8](=[O:9])[CH2:7][NH:6][C:2]([CH3:1])([CH3:5])[CH2:3][CH3:4])[CH:30]=[CH:29][C:13]=1[OH:14]

参加物

3

反応物 1

HCID 22314545HCID 22314545、化合物

生成物 1

HCID 223145401-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

25 g of 2-(1,1-dimethylpropylamino)-1-(4-methoxy-2,2-diphenylbenzo[1,3]dioxol-5-yl) ethanone is refluxed with 50 mL of 15% methanolic hydrochloric acid for 2 hours with stirring. The solvent is distilled off under reduced pressure and the residue is dissolved in acetonitrile and combined with ethyl acetate. The precipitated crystals are suction filtered and washed with acetonitrile and diethyl ether. Yield: 15 g (92%) of the compound as the hydrochloride.

後処理

  1. distillationThe solvent is distilled off under reduced pressure
  2. dissolutionthe residue is dissolved in acetonitrile
  3. filtrationfiltered
  4. washwashed with acetonitrile and diethyl ether

出典と根拠

ORDレコード
ord-1d0a380a21a44297a99d2ed5dcfd711a
出典データセット
uspto-grants-2005_10
特許番号
US06951888B2

反応ノート

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