1-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone → 4-[2-(1,1-Dimethylpropylamino)-1-hydroxyethyl]-3-methoxybenzene-1,2-diol

HRID 966096ノート

反応式

HRID 966096 の反応式
[OH:1][C:2]1[C:3]([O:18][CH3:19])=[C:4]([C:9](=[O:17])[CH2:10][NH:11][C:12]([CH3:16])([CH3:15])[CH2:13][CH3:14])[CH:5]=[CH:6][C:7]=1[OH:8]>[Pt]=O.CO>[CH3:16][C:12]([NH:11][CH2:10][CH:9]([C:4]1[C:3]([O:18][CH3:19])=[C:2]([OH:1])[C:7]([OH:8])=[CH:6][CH:5]=1)[OH:17])([CH3:15])[CH2:13][CH3:14]

参加物

4

反応物 1

HCID 223145401-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

生成物 1

HCID 98168584-[2-(1,1-Dimethylpropylamino)-1-hydroxyethyl]-3-methoxybenzene-1,2-diol

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 887Methanol溶媒

実験手順

6.5 g of 1-(3,4-dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone are hydrogenated with 0.1 g of platinum oxide as catalyst in 125 mL of methanol. The catalyst is suction filtered and the solvent is distilled off under reduced pressure. The residue is dissolved in ethyl acetate, the precipitated crystals are suction filtered and washed with ethyl acetate and diethyl ether. Yield: 5.5 g (85%; benzoate); melting point: 172° C.-174° C.

後処理

  1. filtrationfiltered
  2. distillationthe solvent is distilled off under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. filtrationfiltered
  5. washwashed with ethyl acetate and diethyl ether

出典と根拠

ORDレコード
ord-01686959d43443dd92dfca8b55abfffa
出典データセット
uspto-grants-2005_10
特許番号
US06951888B2

反応ノート

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