HCID 10356117、化合物 → HCID 10093825、化合物

反応式

Cl[C:2]1[C:7]2=[C:8]([CH:17]([CH3:19])[CH3:18])[C:9]([C:11]3[O:12][C:13]([CH3:16])=[CH:14][N:15]=3)=[CH:10][N:6]2[N:5]=[CH:4][N:3]=1.[NH2:20][C:21]1[CH:22]=[C:23]([CH:29]=[CH:30][C:31]=1[F:32])[C:24]([NH:26][O:27][CH3:28])=[O:25]>CN(C)C=O.C(OCC)(=O)C>[F:32][C:31]1[CH:30]=[CH:29][C:23]([C:24]([NH:26][O:27][CH3:28])=[O:25])=[CH:22][C:21]=1[NH:20][C:2]1[C:7]2=[C:8]([CH:17]([CH3:19])[CH3:18])[C:9]([C:11]3[O:12][C:13]([CH3:16])=[CH:14][N:15]=3)=[CH:10][N:6]2[N:5]=[CH:4][N:3]=1

参加物

実験手順

To a solution of Example 58 (30 mg, 0.11 mmol) in dimethyl formamide (0.7 mL) at RT was added 3-amino-4-fluoro-N-methoxy-benzamide (30 mg, 0.16 mmol). After stirring at ambient temperature for 19 h, the mixture was dissolved in ethyl acetate and washed with 10% LiCl solution. The organic layer was separated, dried and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with 5% methanol in chloroform to afford the title compound (22 mg, 48%) as an off-white solid. LC/MS; (M+H)+=425.1.