Dimethylamine → [3-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-propyl]-dimethyl-amine

反応式

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([O:17][CH2:18][CH2:19][CH2:20]Br)=[CH:16][C:11]=3[S:10][N:9]=2)=[CH:4][CH:3]=1.[CH3:22][NH:23][CH3:24]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([O:17][CH2:18][CH2:19][CH2:20][N:23]([CH3:24])[CH3:22])=[CH:16][C:11]=3[S:10][N:9]=2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 674Dimethylamine

HCID 223140693-(4-Bromo-phenyl)-6-(3-bromo-propoxy)-benzo[d]isothiazole

生成物 1

HCID 22313994[3-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-propyl]-dimethyl-amine

実験手順

In analogy to example 3.1, 3-(4-Bromo-phenyl)-6-(3-bromo-propoxy)-benzo[d]isothiazole and Dimethylamine were converted to yield [3-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-propyl]-dimethyl-amine as white semisolid, MS: 391 (MH+, 1Br).

出典と根拠

ORDレコード: ord-a233eb2bd36d4f1aa59bb82ebd1b4059
出典データセット: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06951879B2

反応ノート

読み込み中…