Methanesulfonyl chloride → HCID 86585429、化合物

反応式

[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([C:11]#[C:12][CH2:13][CH2:14][CH2:15][OH:16])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=1.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([C:11]#[C:12][CH2:13][CH2:14][CH2:15][O:16][S:28]([CH3:27])(=[O:30])=[O:29])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:17]1[CH:18]=[CH:19][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:21][CH:22]=1

参加物

反応物 2

HCID 31297Methanesulfonyl chloride

HCID 22313974HCID 22313974、化合物

生成物 1

HCID 86585429HCID 86585429、化合物

実験手順

In analogy to example 21.1, the 5-[2-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl]-pent-4-yn-1-ol was treated with methanesulfonic acid chloride to yield the Methanesulfonic acid 5-[2-methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl]-pent-4-ynyl ester as yellow oil, MS: 452 (M+).

出典と根拠

ORDレコード: ord-55445b08ffa44b53a58c4245a9cb78d9
出典データセット: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06951879B2

反応ノート

読み込み中…