Hydrochloric Acid → 2-Methyl-2-phenylpropanal

温度

10 °C

To a solution of 2-methyl-2-phenylpropanenitrile (290 g, 2.00 mol) in hexane (2000 mL) at 0° C. under N2 is added diisobutylaluminum hydride (DIBAL-H) (2600 mL, 1M in hexane) over a period of 80 minutes. The reaction mixture is stirred at 6-14° C. for 15 minutes, then allowed to warm to room temperature and stirred for 4 hours. The reaction mixture is cooled to 0° C. and H2O (50 mL) is added slowly during 1 hour. Aqueous HCl (900 mL, 15%) is then added slowly to maintain a gentle reflux. The reaction mixture is stirred for 17 hours and the organic phase is separated. The aqueous layer is extracted with ethyl acetate (400 mL) and the combined organic layers are washed with water (300 mL), brine (300 mL) and dried over Na2SO4. The organic extracts are filtered and concentrated to give 2-methyl-2-phenylpropanal as an oil (275 g, 92.8% yield, 98.2% by HPLC area).

1. temperatureto warm to room temperature
2. stirringstirred for 4 hours
3. temperatureThe reaction mixture is cooled to 0° C.
4. temperatureto maintain a gentle reflux
5. stirringThe reaction mixture is stirred for 17 hours
6. customthe organic phase is separated
7. extractionThe aqueous layer is extracted with ethyl acetate (400 mL)
8. washthe combined organic layers are washed with water (300 mL), brine (300 mL)
9. dry with materialdried over Na2SO4
10. filtrationThe organic extracts are filtered
11. concentrationconcentrated

ORDレコード

ord-80048eaa13e74f39937b452dbf3181fe

出典データセット

uspto-grants-2005_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06951955B2