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Triphenylphosphine → 2-Methyl-5-[2-[4-(trifluoromethyl)phenoxy]ethyl]furan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| 反応物 | Dibenzyl azodicarboxylate | HCID 5387121 | — |
| 反応物 | 2-(5-Methylfuran-2-yl)ethan-1-ol | HCID 11062390 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Methyl-5-[2-[4-(trifluoromethyl)phenoxy]ethyl]furan | HCID 21874907 | 66.5% |
反応手順
To a solution of triphenylphosphine (1.56 g, 5.95 mmol) in THF (40 mL) was added DBAD (1.37 g, 5.95 mmol). After 10 min, 4-trifluoromethylphenol (0.964 g, 5.95 mmol) was added. After 10 additional minutes, compound 21A (0.500 g, 3.97 mmol) was added. After 14 h at 25° C., the reaction was concentrated in vacuo and purified by flash chromatography on silica eluting with chloroform to give 0.713 g (44%) of compound 232A as a clear oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06953679B2 |
| 出典データセット | uspto-grants-2005_10 |
| ORD ID | ord-8b09c4284ffc40a9b9f3d72ee45d7aa9 |
| 出典メモ | uspto-grants-2005_10 |