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Ethanaminium, N,N,N-triethyl-, fluoride (1:1) → {3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanaminium, N,N,N-triethyl-, fluoride (1:1) | HCID 69582 | — |
| 反応物 | Triisopropyl({3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methoxy)silane | HCID 21986319 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | {3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol | HCID 21986356 | — |
反応手順
A mixture of triisopropyl({3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methoxy)silane (intermediate 117, 0.97 g) in tetrahydrofuran (30 ml) was treated with tetraethylammonium fluoride (0.392 g) and the reaction mixture stirred at ambient temperature for 1 hour. The solvent was evaporated and the residue purified by flash column chromatography using cyclohexane:ethyl acetate (2:1) as eluent to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091237B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-edda2177b7974f31a0a1889e8a802dc0 |
| 出典メモ | uspto-grants-2006_08 |