dimethyl (2R)-2-methoxybutanedioate → (R)-methoxy-succinic acid

HRID 967616ノート

反応式

HRID 967616 の反応式
C[O:2][C:3](=[O:12])[C@H:4]([O:10][CH3:11])[CH2:5][C:6]([O:8]C)=[O:7]>Cl>[CH3:11][O:10][C@H:4]([CH2:5][C:6]([OH:8])=[O:7])[C:3]([OH:12])=[O:2]

参加物

3

反応物 1

HCID 2192492dimethyl (2R)-2-methoxybutanedioate

生成物 1

HCID 5325475(R)-methoxy-succinic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

The above (R)-2-methoxysuccinic acid dimethyl ester was suspended in 2 N aqueous hydrochloric acid, and heated to reflux for 30 min to give a clear solution. Upon evaporation of solvent in vacuo a quantitative yield of 2(R)-methoxysuccinic acid was obtained as an oil. The oil was redissolved in acetic anhydride (120 mL) and heated to 110° C. for 2 hours. Solvent was removed by rotary evaporation to leave an oil. Ice cooled methanol (150 mL) was added, and the mixture was stirred for 3 hours at 0° C. followed by 16 hours at room temperature. The solvent was removed to leave (R)-2-methoxysuccinic acid 1-methyl ester.

後処理

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. customto give a clear solution

出典と根拠

ORDレコード
ord-2820dc517cdb41eb8223c9da2992401a
出典データセット
uspto-grants-2005_10
特許番号
US06953812B2

反応ノート

読み込み中…