{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol → {5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

HRID 9677

反応式

HRID 9677 の反応式
CC1C=C(C2C=CC(OC(F)(F)[F:15])=CC=2)SC=1CO.F[C:21]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[C:24]([F:31])=[CH:23][C:22]=1[C:32]1[S:36][C:35]([CH2:37][O:38][Si](C(C)C)(C(C)C)C(C)C)=[C:34]([CH3:49])[CH:33]=1>>[F:15][C:23]1[C:24]([F:31])=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=[CH:21][C:22]=1[C:32]1[S:36][C:35]([CH2:37][OH:38])=[C:34]([CH3:49])[CH:33]=1

参加物

3

反応物 2

HCID 21986356{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol2 回HCID 69591148({5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane2 回

生成物 1

HCID 21986476{5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

実験手順

The title compound was prepared using a method analogous to that used for the preparation of {3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol (intermediate 118) using ({5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane (intermediate 121).

出典と根拠

ORDレコード
ord-2e228b351c7c43fba1014b597e7acab5
出典データセット
uspto-grants-2006_08
特許番号
US07091237B2

関連ノート

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