1-Benzyl-4-(4-carboxyphenoxymethyl)piperidin-4-ol → 1-Benzyl-4-(4-methoxycarbonylphenoxymethyl)piperidin-4-ol

HRID 967770ノート

反応式

HRID 967770 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=2)([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:26][Si](C=[N+]=[N-])(C)C.CCCCCC>CO>[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:19][CH:18]=2)([OH:14])[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 222912941-Benzyl-4-(4-carboxyphenoxymethyl)piperidin-4-olHCID 86587183Trimethylsilyldiazomethane hexane

生成物 1

HCID 222912651-Benzyl-4-(4-methoxycarbonylphenoxymethyl)piperidin-4-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound (0.86 g) obtained in Step 4 was dissolved in methanol (10 mL) and to the solution was added a 2M trimethylsilyidiazomethan-hexane solution (1.3 mL). After completion of the reaction, the residue from which the solvent was removed under reduced pressure was purified by silica gel column chromatography (Chromatorex NH™) (eluent; ethyl acetate:hexane=1:19 to 1:9) to obtain the titled compound (0.8 g) as crystals.

後処理

  1. customAfter completion of the reaction
  2. customthe residue from which the solvent was removed under reduced pressure
  3. customwas purified by silica gel column chromatography (Chromatorex NH™) (eluent; ethyl acetate:hexane=1:19 to 1:9)

出典と根拠

ORDレコード
ord-977f295bf3f34f6e9fe71dfc1a2dc284
出典データセット
uspto-grants-2005_10
特許番号
US06956046B2

反応ノート

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