1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol → 1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

HRID 967774ノート

反応式

HRID 967774 の反応式
[ClH:1].CO.[C:4]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:8][CH:7]=1)#[N:5]>CO>[ClH:1].[C:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:10][CH:11]=1)#[N:5]

参加物

4

反応物 2

HCID 102916131-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-olHCID 21893726Hydrochloride methanol

生成物 1

HCID 222912871-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

10% hydrochloric acid-methanol (0.2 mL) was added to a methanol solution (2 mL) of the compound (50 mg) obtained in Step 4 of Example 1. After the solvent was removed under reduced pressure, the residue obtained was crystallized from ether and collected by filtration to obtain the titled compound (48 mg) as crystals.

後処理

  1. customAfter the solvent was removed under reduced pressure
  2. customthe residue obtained
  3. customwas crystallized from ether
  4. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-aa80d6da31a1439097d934d520db2c33
出典データセット
uspto-grants-2005_10
特許番号
US06956046B2

反応ノート

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