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HRID 9678作成日：2026年10月25日

{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol → {5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

https://huagongshe.com/reaction/9678

反応式

関与物質

役割名称HCID仕込み量
反応物{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanolHCID 21986356—
反応物({5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silaneHCID 69591680—
生成物{5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanolHCID 21986424—

反応手順

The title compound was prepared using a method analogous to that used for the preparation of {{3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol (intermediate 118) using ({5-[2-fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane (intermediate 123).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07091237B2
出典データセットuspto-grants-2006_08
ORD IDord-ab42de0f5742458eae6065e2d141c665
出典メモuspto-grants-2006_08