2-Chlorobenzenesulfonamide → 2-chloro-N-{[(2-{4-[2-ethyl-4-(4-fluorophenyl)-1H-imidazol-1-yl]phenyl}ethyl)amino]carbonyl}benzenesulfonamide

HRID 967836

反応式

HRID 967836 の反応式
[CH2:1]([C:3]1[N:4]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][NH:23][C:24](=O)[O:25]C3C=CC=CC=3)=[CH:17][CH:16]=2)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:7]=1)[CH3:2].[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[S:40]([NH2:43])(=[O:42])=[O:41]>>[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[S:40]([NH:43][C:24]([NH:23][CH2:22][CH2:21][C:18]1[CH:17]=[CH:16][C:15]([N:4]2[CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=3)[N:7]=[C:3]2[CH2:1][CH3:2])=[CH:20][CH:19]=1)=[O:25])(=[O:42])=[O:41]

参加物

3

反応物 2

HCID 814102-ChlorobenzenesulfonamideHCID 22291420phenyl 2-{4-[2-ethyl-4-(4-fluorophenyl)-1H-imidazol-1-yl]phenyl}ethylcarbamate

生成物 1

HCID 222914132-chloro-N-{[(2-{4-[2-ethyl-4-(4-fluorophenyl)-1H-imidazol-1-yl]phenyl}ethyl)amino]carbonyl}benzenesulfonamide

実験手順

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-{4-[2-ethyl-4-(4-fluorophenyl)-1H-imidazol-1-yl]phenyl}ethylcarbamate and 2-chlorobenzenesulfonamide. MS (ESI) m/z 527 [M+H]+, 525 [M−H]−, 1H-NMR (CDCl3)δ1.25 (3H, t, J=7.5 Hz), 2.71 (2H, q, J=7.5 Hz), 2.85 (2H, t, J=7.0 Hz), 3.47-3.54 (2H, m), 6.57 (1H, br), 7.07 (2H, t, J=8.8 Hz), 7.19 (1H, s), 7.26 (2H, s), 7.40-7.46 (1H, m), 7.57-7.61 (2H, m), 7.73-7.78 (2H, m), 8.00 (2H, d, J=7.5 Hz).

出典と根拠

ORDレコード
ord-723338fa39a047d3bc343c2f60528e41
出典データセット
uspto-grants-2005_10
特許番号
US06956050B2

関連ノート

読み込み中…