4-Chlorobenzenesulfonyl isocyanate → 4-chloro-N-{[(2-{4-[2-ethyl-4-(6-methylpyridin-2-yl)-1H-imidazol-1-yl]phenyl}ethyl)amino]carbonyl}benzenesulfonamide

HRID 967858

反応式

HRID 967858 の反応式
[CH2:1]([C:3]1[N:4]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][NH:23][C:24](=[O:30])OC(C)(C)C)=[CH:17][CH:16]=2)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[N:7]=1)[CH3:2].[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([S:38]([N:41]=C=O)(=[O:40])=[O:39])=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:33]=[CH:34][C:35]([S:38]([NH:41][C:24]([NH:23][CH2:22][CH2:21][C:18]2[CH:19]=[CH:20][C:15]([N:4]3[CH:5]=[C:6]([C:8]4[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=4)[N:7]=[C:3]3[CH2:1][CH3:2])=[CH:16][CH:17]=2)=[O:30])(=[O:39])=[O:40])=[CH:36][CH:37]=1

参加物

3

反応物 2

HCID 1385874-Chlorobenzenesulfonyl isocyanateHCID 22291410tert-butyl 2-{4-[2-ethyl-4-(6-methylpyridin-2-yl)-1H-imidazol-1-yl]phenyl]ethylcarbamate

生成物 1

HCID 222913744-chloro-N-{[(2-{4-[2-ethyl-4-(6-methylpyridin-2-yl)-1H-imidazol-1-yl]phenyl}ethyl)amino]carbonyl}benzenesulfonamide

実験手順

The title compound was prepared according to the procedure described in step 5 of Example 26 from tert-butyl 2-{4-[2-ethyl-4-(6-methylpyridin-2-yl)-1H-imidazol-1-yl]phenyl}ethylcarbamate and 4-chlorobenzenesulfonyl isocyanate. MS (ESI) m/z 524 [M+H]+, 522 [M−H]−, 1H-NMR (DMSO d-6)δ1.20 (3H, t, J=7.3 Hz), 2.49 (3H, s), 2.67 (2H, q, J=7.5 Hz), 2.78 (2H, t, J=7.1 Hz), 3.25-3.32 (2H, m), 6.66 (1H, t, J=5.5 Hz), 7.10 (2H, 1, J=6.4 Hz), 7.33 (2H, d, J=8.4 Hz), 7.42 (2H, d, J=8.4 Hz), 7.7-7.76 (4H, m), 7.93 (1H, d, J=8.6 Hz).

出典と根拠

ORDレコード
ord-585dc8357e1d415abe6c7517a77a5281
出典データセット
uspto-grants-2005_10
特許番号
US06956050B2

関連ノート

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