Diazomethane → Methyl 5-methyl-4-hexenoate

HRID 968155

反応式

HRID 968155 の反応式
[N+](=[CH2:3])=[N-].[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10]>CCOCC>[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([O:11][CH3:3])=[O:10]

参加物

4

反応物 2

HCID 9550DiazomethaneHCID 124253245-Methyl-4-hexenoic acid

生成物 1

HCID 10909672Methyl 5-methyl-4-hexenoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

Freshly prepared diazomethane in ether was added to an ice-cooled solution of 5-methyl-4-hexenoic acid (4.5 g, 35.16 mmol) in ether (10 mL) until the solution became slightly yellow in color. The solvent was then evaporated under vacuum to afford the title product as a colorless liquid in near quantitative yield (4.90 g). This product was used in the next reaction step without further purification. 1H NMR (CDCl3) δ 1.62 & 1.68 [2s, 6H, C(CH3)2], 2.30 [m, 4H, (CH2)2], 3.69 (s, 3H, COOCH3) and 5.07 (t, 1H, CH).

後処理

  1. customThe solvent was then evaporated under vacuum

出典と根拠

ORDレコード
ord-a4194a816e5d43c4b8b86099f8298317
出典データセット
uspto-grants-2005_10
特許番号
US06958141B2

関連ノート

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