Sodium Methoxide → [2-Methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea

HRID 968537ノート

反応式

HRID 968537 の反応式
C([NH:9][C:10]([NH:12][C:13]1[CH:18]=[C:17]([CH:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:16]=[CH:15][C:14]=1[O:25][CH3:26])=[S:11])(=O)C1C=CC=CC=1.C[O-].[Na+]>CO>[CH3:26][O:25][C:14]1[CH:15]=[CH:16][C:17]([CH:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)=[CH:18][C:13]=1[NH:12][C:10]([NH2:9])=[S:11]

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 227195711-Benzoyl-3-[2-methoxy-5-(tetrahydropyran-4-yl)-phenyl]-thiourea

生成物 1

HCID 22015747[2-Methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1-benzoyl-3-[2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea (X) in methanol is added sodium methylate solution and stirring continued for about 1 h at room temperature. The product (XI) [2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea is isolated by conventional means.

出典と根拠

ORDレコード
ord-a782e1606e434c12b23ef122ad852623
出典データセット
uspto-grants-2007_12
特許番号
US07304058B2

反応ノート

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