2-(Trichloroacetyl)pyrrole → 1-[5-(Trichloroacetyl)-1H-pyrrol-3-yl]propan-1-one
反応式
[Cl:1][C:2]([Cl:11])([Cl:10])[C:3]([C:5]1[NH:6][CH:7]=[CH:8][CH:9]=1)=[O:4].[Cl-].[Cl-].[Cl-].[Al+3]>ClCCl>[Cl:11][C:2]([Cl:1])([Cl:10])[C:3]([C:5]1[NH:6][CH:7]=[C:8]([C:3](=[O:4])[CH2:5][CH3:9])[CH:9]=1)=[O:4]参加物
4
実験手順
In a dry flask, 3-proprionyl chloride (1 equivalent) was combined with 2-trichloroacetyl pyrrole (1 equivalent) in a minimum amount of dichloromethane (DCM). To the resulting solution, at ambient temperature, was added aluminum trichloride (1 equivalent). After 2 hours, the reaction mixture was applied directly onto a silica gel column. Gradient elution with 10% ethyl acetate to 50% ethyl acetate in hexanes provided the title compound 2.
後処理
- washGradient elution with 10% ethyl acetate to 50% ethyl acetate in hexanes
出典と根拠
- ORDレコード
- ord-c086db4f0ee040d3bf902ee220d9cfb8
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07304061B2
反応ノート
読み込み中…