HCID 22030186、化合物 → HCID 22030009、化合物
反応式
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:5][CH:4]=1>Br.CC(O)=O>[F:17][C:15]([F:16])([F:18])[C:14]1[C:9]([C:6]2[CH:5]=[CH:4][C:3](=[O:2])[NH:8][CH:7]=2)=[N:10][CH:11]=[CH:12][CH:13]=1参加物
3
実験手順
Heat 6′-methoxy-3-trifluoromethyl-[2,3′]bipyridinyl (41 g, 0.16 mol) in 30% HBr/AcOH (100 mL) to reflux for 1 hour. Cool the mixture and filter, and wash the precipitate with ether (100 mL). Transfer the precipitate into 10M sodium hydroxide (500 mL) and stir for 1 hour, and treat the solution with hydrochloric acid until the solution is pH 7. Collect the white solid by filtration and air dry to give the title compound (36 g, 93%) as a white solid.
後処理
- temperatureto reflux for 1 hour
- temperatureCool the mixture
- filtrationfilter
- washwash the precipitate with ether (100 mL)
- additiontreat the solution with hydrochloric acid until the solution
- customCollect the white solid
- filtrationby filtration and air
- customdry
出典と根拠
- ORDレコード
- ord-f57dcbc3655942efb2b02382a245f0de
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07304059B2
反応ノート
読み込み中…