化工社化工社 化学情報印刷レポート · 研究参考用
Stannous Chloride → 4-Benzyloxy-2-fluorophenylhydrazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 4-(Benzyloxy)-2-fluoroaniline | HCID 11499809 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Benzyloxy-2-fluorophenylhydrazine hydrochloride | HCID 11637567 | 77.2% |
反応手順
A solution of NaNO2 (1.38 g) in H2O (8 mL) was added to a suspension of 4-benzyloxy-2-fluoroaniline (5.0 g) in 6N HCl (24 mL) at 0° C. After 30 minutes stirring, a solution of SnCl2 (7.7 g) in 6N HCl (24 mL) was added to the mixture at 0° C. The mixture was allowed to warm to room temperature and stirred for 1.5 hours to produce a precipitate. The precipitate was collected by filtration to yield 4.15 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07304072B2 |
| 出典データセット | uspto-grants-2007_12 |
| ORD ID | ord-48f7b1f6e34446d7bcf428095382b934 |
| 出典メモ | uspto-grants-2007_12 |