Acetic Anhydride → 3-Acetamido-4-methylbenzoic acid
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(O)(=O)C>[C:12]([NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6])(=[O:14])[CH3:13]参加物
4
反応条件
- 温度
- 60 °C
実験手順
A mixture of 3-amino-4-methylbenzoic acid (13) (27.23 g, 180.2 mmol) and acetic acid (190 mL) is heated to 60° C., and acetic anhydride (120 mL, 1300 mmol) is introduced to the reaction mixture over about 0.25 hours. The reaction mixture is then heated to reflux and stirred for about 30 minutes. The mixture is then cooled to room temperature, and the solid obtained is filtered, washed with water (100 mL), and dried to provide 3-(Acetylamino)-4-methylbenzoic Acid (14) as a light pink colored solid (26.37 g, 76% Yield).
後処理
- temperatureThe reaction mixture is then heated
- temperatureto reflux
- temperatureThe mixture is then cooled to room temperature
- customthe solid obtained
- filtrationis filtered
- washwashed with water (100 mL)
- customdried
出典と根拠
- ORDレコード
- ord-5656d06a0eba4b70abe4bfc0449c877a
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07304084B2
反応ノート
読み込み中…