Acetic Anhydride → 3-Acetamido-4-methylbenzoic acid

HRID 968789

反応式

HRID 968789 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(O)(=O)C>[C:12]([NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6])(=[O:14])[CH3:13]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 755683-Amino-4-methylbenzoic acid

生成物 1

HCID 2434323-Acetamido-4-methylbenzoic acid収率 76%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
60 °C

実験手順

A mixture of 3-amino-4-methylbenzoic acid (13) (27.23 g, 180.2 mmol) and acetic acid (190 mL) is heated to 60° C., and acetic anhydride (120 mL, 1300 mmol) is introduced to the reaction mixture over about 0.25 hours. The reaction mixture is then heated to reflux and stirred for about 30 minutes. The mixture is then cooled to room temperature, and the solid obtained is filtered, washed with water (100 mL), and dried to provide 3-(Acetylamino)-4-methylbenzoic Acid (14) as a light pink colored solid (26.37 g, 76% Yield).

後処理

  1. temperatureThe reaction mixture is then heated
  2. temperatureto reflux
  3. temperatureThe mixture is then cooled to room temperature
  4. customthe solid obtained
  5. filtrationis filtered
  6. washwashed with water (100 mL)
  7. customdried

出典と根拠

ORDレコード
ord-5656d06a0eba4b70abe4bfc0449c877a
出典データセット
uspto-grants-2007_12
特許番号
US07304084B2

関連ノート

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