Sulfamide → 4-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamide

HRID 969548ノート

反応式

HRID 969548 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:8][CH2:7]1.[S:22](N)([NH2:25])(=[O:24])=[O:23]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH:12]2[CH2:13][CH2:14][N:15]([S:22]([NH2:25])(=[O:24])=[O:23])[CH2:16][CH2:17]2)[CH2:10][CH2:11]1

参加物

4

反応物 2

HCID 82267SulfamideHCID 223974344-(3,4-Dichloro-phenoxy)-[1,4']bipiperidine

生成物 1

HCID 231027624-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamide収率 80.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4-(3,4-Dichlorophenoxy)-1,4′-bipiperidine (5 g, 0.0152 mol) and sulfamide (1.45 g, 0.0152 mol) were stirred together in dioxan (150 ml) at reflux for 24 hours. The resulting mixture was cooled to ambient temperature, evaporated to dryness and the residue was triturated with ether to give the title compound as a tan solid (5 g; MS APCI 409/411 (M+H)).

後処理

  1. temperatureat reflux for 24 hours
  2. customevaporated to dryness
  3. customthe residue was triturated with ether

出典と根拠

ORDレコード
ord-d4eb8159bf6f4990b3a63ba470156b55
出典データセット
uspto-grants-2007_12
特許番号
US07307090B2

反応ノート

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