2-(2-Methyl-1H-imidazol-1-yl)ethan-1-amine → N-[2-(2-Methylimidazol-1-yl)ethyl]-2-phenylbenzoxazole-4-carboxamide

HRID 969806

反応式

HRID 969806 の反応式
[CH3:1][C:2]1[N:3]([CH2:7][CH2:8][NH2:9])[CH:4]=[CH:5][N:6]=1.[C:10]1([C:16]2[O:17][C:18]3[C:19](=[C:21]([C:25](O)=[O:26])[CH:22]=[CH:23][CH:24]=3)[N:20]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH3:1][C:2]1[N:3]([CH2:7][CH2:8][NH:9][C:25]([C:21]2[CH:22]=[CH:23][CH:24]=[C:18]3[O:17][C:16]([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)=[N:20][C:19]=23)=[O:26])[CH:4]=[CH:5][N:6]=1

参加物

3

反応物 2

HCID 31574802-(2-Methyl-1H-imidazol-1-yl)ethan-1-amineHCID 108683692-Phenylbenzoxazole-4-carboxylic acid

生成物 1

HCID 11717192N-[2-(2-Methylimidazol-1-yl)ethyl]-2-phenylbenzoxazole-4-carboxamide収率 35%

実験手順

N-[2-(2-Methylimidazol-1-yl)ethyl]-2-phenylbenzoxazole-4-carboxamide was prepared from 2-(2-methylimidazol-1-yl)ethylamine and 2-phenylbenzoxazole-4-carboxylic acid using the conditions described in Step C of Example 1. This compound was obtained in 35% yield as a white solid; mp 125-127° C.; 1H NMR (300 MHz, CD3OD) δ 8.11 (dd, J=7.8, 1.0 Hz, 2H), 7.96 (d, J=7.8 Hz, 1H), 7.73 (d, J=8.2 Hz, 1H), 7.63-7.52 (m, 3H), 7.42 (t, J=8.0 Hz, 1H), 7.13 (s, 1H), 6.86 (s, 1H), 4.22 (t, J=5.8 Hz, 2H), 3.87 (t, J=6.0 Hz, 2H), 2.34 (s, 3H); MS (APCI) m/z 347 [M+H]+

後処理

  1. customThis compound was obtained in 35% yield as a white solid

出典と根拠

ORDレコード
ord-5f253537023c4254accc5109de7e3703
出典データセット
uspto-grants-2007_12
特許番号
US07307094B2

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