化工社化工社 化学情報印刷レポート · 研究参考用
Lithium Hydroxide → 5-Chloro-2-phenylbenzoxazole-7-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate | HCID 68454443 | — |
| 生成物 | 5-Chloro-2-phenylbenzoxazole-7-carboxylic acid | HCID 68456500 | 82% |
反応手順
5-Chloro-2-phenylbenzoxazole-7-carboxylic acid was prepared from methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate via lithium hydroxide mediated hydrolysis as described in Step B of Example 14. This material was obtained as a white solid in 82% yield. 1H NMR (300 MHz, DMSO-d6) δ 13.84 (br s, 1H), 8.22-8.19 (m, 3H), 7.85 (d, J=2.1 Hz, 1H), 7.70-7.63 (m, 3H), 4.07 (s, 3H); MS (ESI) m/z 274 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07307094B2 |
| 出典データセット | uspto-grants-2007_12 |
| ORD ID | ord-c914d5351e1745a3a50e67d9fb59b9b7 |
| 出典メモ | uspto-grants-2007_12 |