SK&F 81297 → Dopamine

HRID 969924

反応式

HRID 969924 の反応式
CCCN1[C@@H]2CC3C4C(=CC=CC=4NC=3)[C@H]2C[C@@H](CSC)C1.C1[C:33]2[C:28](=[CH:29][C:30]([OH:36])=[C:31]([OH:35])[C:32]=2Cl)[CH:27](C2C=CC=CC=2)[CH2:26][NH:25]C1>>[NH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:35])=[C:30]([OH:36])[CH:29]=1

参加物

3

反応物 2

HCID 1218SK&F 81297HCID 47811Pergolide

生成物 1

HCID 681Dopamine

実験手順

HEK cells were transfected with a DNA construct encoding D1-NLS-GFP (1.5 micrograms of DNA), and incubated with the agonist pergolide (10 micromolar) for 48 hours. At 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium containing SKF-81297 (final concentration 10 micromolar). The cells were examined by confocal microscopy.

後処理

  1. additionAt 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium

出典と根拠

ORDレコード
ord-2520ff19e1914f34831d55f530327735
出典データセット
uspto-grants-2007_12
特許番号
US07309576B2

関連ノート

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