Chlorosuccinimide → Methyl 6-amino-5-bromo-3-chloropyridine-2-carboxylate

HRID 970381ノート

反応式

HRID 970381 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[Br:12].[Cl:13]N1C(=O)CCC1=O>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[C:5]([Cl:13])=[CH:4][C:3]=1[Br:12]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 10704661Methyl 6-amino-5-bromopicolinate

生成物 1

HCID 21873807Methyl 6-amino-5-bromo-3-chloropyridine-2-carboxylate収率 95.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of methyl 6-amino-5-bromopyridine-2-carboxylate (20.04 g) in acetic acid (900 mL) was added N-chlorosuccinimide (13.96 g) and the resultant solution was heated to 120° C. for 1 hour. The solution was then evaporated and treated with excess aqueous sodium bicarbonate and extracted with dichloromethane. The organic fraction was dried and evaporated to give the product (21.98 g).

後処理

  1. customThe solution was then evaporated
  2. additiontreated with excess aqueous sodium bicarbonate
  3. extractionextracted with dichloromethane
  4. customThe organic fraction was dried
  5. customevaporated

出典と根拠

ORDレコード
ord-843bb1eecd8a453a8afee779bc9d9cff
出典データセット
uspto-grants-2007_12
特許番号
US07312212B2

反応ノート

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