Dimethyl Sulfide → 7-Chloro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde

7-Chloro-6-((E)-styryl)-4H-pyrido[3,2-b][1,4]oxazin-3-one (15b) (8.0 g, 27.9 mmole) was dissolved in a mixture of DMF (400 mL) and methanol (40 mL), and the solution was cooled to −78° C. Ozone was bubbled through the solution with stirring for 45 minutes, then the excess ozone was removed by bubbling oxygen through the solution for 30 min. Dimethylsulfide (21 mL, 279 mmole) was added to the solution, and the reaction was stirred at −78° C. for 3 hr, then at room temperature overnight. The solvent was removed in vacuo, and the residue was triturated with Et2O (150 mL). The collected solid was washed with additional Et2O and dried to afford a white solid (4 g, 68%).

1. customOzone was bubbled through the solution
2. customthe excess ozone was removed
3. customby bubbling oxygen through the solution for 30 min
4. stirringthe reaction was stirred at −78° C. for 3 hr
5. customat room temperature
6. customovernight
7. customThe solvent was removed in vacuo
8. customthe residue was triturated with Et2O (150 mL)
9. washThe collected solid was washed with additional Et2O
10. customdried

ORDレコード

ord-feedd6a2e1b248a9ba7ea1b9aeb6f989

出典データセット

uspto-grants-2007_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07312212B2