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Malononitrile → ST050948
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Malononitrile | HCID 8010 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Cyclohexanone, 2-hydroxy- | HCID 10785 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | ST050948 | HCID 673083 | 81.9% |
反応手順
2.1 4.8 ml of triethylamine are added dropwise to a solution of 11.0 g of 2-hydroxycyclohexanone and 9.6 g of malononitrile in 25 ml of methanol, and the mixture is stirred at room temperature for a further 4 hours. The crystals which deposit are separated off and washed with methanol, giving 12.8 g of 2-amino-4,5,6,7-tetrahydrobenzofuran-3-carbonitrile (“BA”), m.p. 179°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07312224B2 |
| 出典データセット | uspto-grants-2007_12 |
| ORD ID | ord-4a7c5bb2c2bb4edc850a4550919d89b8 |
| 出典メモ | uspto-grants-2007_12 |