Sulfadiazine → N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride

HRID 970456

反応式

HRID 970456 の反応式
[CH:1]1[CH:2]=[N:3][C:4]([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[N:5][CH:6]=1.[C:18](Cl)([Cl:20])=[S:19].C(N(CC)CC)C>ClCCl>[Cl-:20].[N:3]1[CH:2]=[CH:1][CH:6]=[N:5][C:4]=1[NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][CH:18]=[S:19])=[CH:13][CH:12]=1)(=[O:10])=[O:9]

参加物

5

反応物 3

HCID 5215SulfadiazineHCID 8471TriethylamineHCID 10040Thiophosgene

生成物 1

HCID 86601004N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of sulfadiazine (192 mg, 0.77 mmol) in dichloromethane (20 mL) were slowly added thiophosgene (0.06 mL, 0.83 mmol) and triethylamine (0.05 mL, 0.32 mmol) under cooling with an ice bath. After the reaction mixture was stirred for five hours at room temperature, it was washed with water and brine, dried over anhydrous sodium sulfate, filtered, evaporated and dried under vacuum. The product was used immediately for the next reaction.

後処理

  1. temperatureunder cooling with an ice bath
  2. washit was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customdried under vacuum
  7. customThe product was used immediately for the next reaction

出典と根拠

ORDレコード
ord-b37488ecc727401f901f94bb23d8c7ce
出典データセット
uspto-grants-2007_12
特許番号
US07312226B2

関連ノート

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