化工社化工社 化学情報印刷レポート · 研究参考用
3-Methyl-5-nitroisoquinoline → 3-Methylisoquinolin-5-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methyl-5-nitroisoquinoline | HCID 274973 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Methylisoquinolin-5-amine | HCID 12212055 | 100% |
反応手順
A mixture of 3-methyl-5-nitroisoquinoline (1.3 g, 0.0069 mol—prepared according to the procedure in WO 2004/024710), 10% Pd—C (100 mg) and MeOH (100 mL) was stirred under an atmosphere of hydrogen (1 atm) at rt for 2 h. The mixture was filtered and the filtrate was concentrated under vacuum to give a light yellow solid (1.1 g, 100%). LC-MS: 0.64 min, 159.1 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07312233B2 |
| 出典データセット | uspto-grants-2007_12 |
| ORD ID | ord-709cf56b5bcc40f6b489085696e63440 |
| 出典メモ | uspto-grants-2007_12 |