3-Methyl-5-nitroisoquinoline → 3-Methylisoquinolin-5-amine

HRID 970666

反応式

HRID 970666 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([N+:12]([O-])=O)[CH:8]=[CH:7][CH:6]=2>[Pd].CO>[NH2:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:11]=[C:2]([CH3:1])[N:3]=[CH:4]2

参加物

4

反応物 1

HCID 2749733-Methyl-5-nitroisoquinoline

生成物 1

HCID 122120553-Methylisoquinolin-5-amine収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 3-methyl-5-nitroisoquinoline (1.3 g, 0.0069 mol—prepared according to the procedure in WO 2004/024710), 10% Pd—C (100 mg) and MeOH (100 mL) was stirred under an atmosphere of hydrogen (1 atm) at rt for 2 h. The mixture was filtered and the filtrate was concentrated under vacuum to give a light yellow solid (1.1 g, 100%). LC-MS: 0.64 min, 159.1 (M+1).

後処理

  1. customprepared
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-709cf56b5bcc40f6b489085696e63440
出典データセット
uspto-grants-2007_12
特許番号
US07312233B2

関連ノート

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