関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-4-hydroxybenzothiazole | HCID 24057 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | (Diethoxyphosphoryl)methyl trifluoromethanesulfonate | HCID 11833487 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Amino-4-diethylphosphonomethyloxybenzothiazole | HCID 54277848 | — |
反応手順
A mixture of 2-amino-4-hydroxybenzothiazole (1 mmole) and NaH (1.3 mmole) in DMF (5 L) was stirred at 0° C. for 10 min, and then treated with diethylphosphonomethyl trifluoromethylsulfonate (1.2 mmole). After being stirred at room temperature for 8 h, the reaction was subjected to extraction and chromatography to give 2-amino-4-diethylphosphonomethyloxybenzothiazole as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07312219B2 |
|---|
| 出典データセット | uspto-grants-2007_12 |
|---|
| ORD ID | ord-e00f547c64814cb39b27f09bdc7eda2b |
|---|
| 出典メモ | uspto-grants-2007_12 |
|---|
