2-Amino-4-hydroxybenzothiazole → 2-Amino-4-diethylphosphonomethyloxybenzothiazole

HRID 970713

反応式

HRID 970713 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:5]=2[N:6]=1.[H-].[Na+].FC(S(O[CH2:22][P:23]([O:28][CH2:29][CH3:30])([O:25][CH2:26][CH3:27])=[O:24])(=O)=O)(F)F>CN(C=O)C>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:22][P:23]([O:28][CH2:29][CH3:30])([O:25][CH2:26][CH3:27])=[O:24])[C:5]=2[N:6]=1

参加物

5

反応物 3

HCID 240572-Amino-4-hydroxybenzothiazoleHCID 24758Sodium hydrideHCID 11833487(Diethoxyphosphoryl)methyl trifluoromethanesulfonate

生成物 1

HCID 542778482-Amino-4-diethylphosphonomethyloxybenzothiazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

A mixture of 2-amino-4-hydroxybenzothiazole (1 mmole) and NaH (1.3 mmole) in DMF (5 L) was stirred at 0° C. for 10 min, and then treated with diethylphosphonomethyl trifluoromethylsulfonate (1.2 mmole). After being stirred at room temperature for 8 h, the reaction was subjected to extraction and chromatography to give 2-amino-4-diethylphosphonomethyloxybenzothiazole as an oil.

後処理

  1. stirringAfter being stirred at room temperature for 8 h
  2. extractionthe reaction was subjected to extraction and chromatography

出典と根拠

ORDレコード
ord-e00f547c64814cb39b27f09bdc7eda2b
出典データセット
uspto-grants-2007_12
特許番号
US07312219B2

関連ノート

読み込み中…