Hydrochloric Acid → 4-(Phenoxymethyl)benzoic acid

HRID 970782

反応式

HRID 970782 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Cl[CH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=1.Cl>CS(C)=O.C(=O)(O)[O-].[Na+].O>[O:7]([CH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 996PhenolHCID 14797Potassium HydroxideHCID 742344-(Chloromethyl)benzoic acid

生成物 1

HCID 7372674-(Phenoxymethyl)benzoic acid収率 32.4%

試薬・触媒・溶媒 3

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

Phenol 2 (4.706 g, 50.0 mmol) and KOH (6.172 g, 110 mmol) were combined in dimethyl sulfoxide (DMSO) (250 ml). 4-Chloromethylbenzoic acid 1 (8.530 g, 50.0 mmol) was added. The mixture was stirred at room temperature overnight. The mixture was then poured into H2O and acidified with concentrated HCl. The solution was then extracted and concentrated to give a solid. The solid was dissolved in an aqueous sodium bicarbonate solution, then washed with ethyl acetate. The aqueous mixture was then acidified with dilute HCl forming a precipitate which was filtered and dried to give about 3.7 g of 4-phenoxymethylbenzoic acid 3.

後処理

  1. extractionThe solution was then extracted
  2. concentrationconcentrated
  3. customto give a solid
  4. washwashed with ethyl acetate
  5. filtrationwas filtered
  6. customdried

出典と根拠

ORDレコード
ord-22ac2626e10944b3bbc3e92d5ca95971
出典データセット
uspto-grants-2007_12
特許番号
US07312230B2

関連ノート

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