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Methyl (R)-(+)-2-isocyanato-3-phenylpropionate → (R)-2-(4-Phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| 反応物 | HCID 12990905 | HCID 12990905 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 生成物 | (R)-2-(4-Phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester | HCID 12990906 | 96.9% |
反応手順
(4-Phenethyloxyphenyl)methanol 11(1.141 g, 5.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.036 g, 5.0 mmol) and DMAP (10 mg) were combined and heated until molten and stirred for 20 min. Upon cooling the residue was purified by chromatography to give about 2.1 g of (R)-2-(4-phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 12.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07312230B2 |
| 出典データセット | uspto-grants-2007_12 |
| ORD ID | ord-ba77784cddc34f77b996690868be0c90 |
| 出典メモ | uspto-grants-2007_12 |