Potassium Carbonate → Ethyl (5-bromobenzofuran)-2-carboxylate

HRID 970789

反応式

HRID 970789 の反応式
[Br:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.Br[CH:12](C(OCC)=O)[C:13]([O:15][CH2:16][CH3:17])=[O:14].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][C:6]=2[CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 69637Diethyl bromomalonateHCID 728635-Bromosalicylaldehyde

生成物 1

HCID 735184Ethyl (5-bromobenzofuran)-2-carboxylate収率 26.8%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

反応条件

温度
90 °C

実験手順

A mixture of 5-bromosalicylaldehyde 14 (10 g, 50 mmole), diethyl bromomalonate (13.1 g, 55 mmole), potassium carbonate (6.9 g, 50 mmole), and 2-butanone (80 ml) was stirred at 90° C. for 16 hrs. The solvent was removed under reduced pressure at 45° C., and the residue was acidified with 1M HCl, extracted, washed, dried, and evaporated. The residue was purified by chromatography to give about 3.6 g of ethyl 5-bromo-benzofuran-2-carboxylate 15, mp. 59-60° C.

後処理

  1. customThe solvent was removed under reduced pressure at 45° C.
  2. extractionextracted
  3. washwashed
  4. customdried
  5. customevaporated
  6. customThe residue was purified by chromatography

出典と根拠

ORDレコード
ord-d9fd5ee6a758489f9c7d4e156b97dac0
出典データセット
uspto-grants-2007_12
特許番号
US07312230B2

関連ノート

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