Potassium Carbonate → (5-Phenyl-benzoxazol-2-yl)methanol

HRID 970811ノート

反応式

HRID 970811 の反応式
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([CH2:15][O:16]C(=O)C)=[N:12][C:11]=3[CH:20]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])([O-])=O.[K+].[K+]>CO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([CH2:15][OH:16])=[N:12][C:11]=3[CH:20]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 20622383Acetic Acid 5-phenyl-benzoxazol-2-ylmethyl Ester

生成物 1

HCID 22062842(5-Phenyl-benzoxazol-2-yl)methanol収率 72.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Acetic acid (5-phenyl-benzoxazol-2-yl)methyl ester 50 (409 mg, 1.53 mmol) was dissolved in 10 ml of methanol. Finely ground K2CO3 (53 mg, 0.38 mmol) was added. After 3 hrs, the mixture was concentrated then diluted with water and extracted with ethyl acetate. The extracts were washed with brine, dried, filtered and concentrated to yield about 251 mg of (5-phenyl-benzoxazole-2-yl)methanol 51.

後処理

  1. concentrationthe mixture was concentrated
  2. additionthen diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe extracts were washed with brine
  5. customdried
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-a9128cf1067047e6892d0a4cbda31971
出典データセット
uspto-grants-2007_12
特許番号
US07312230B2

反応ノート

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