Cesium acetate → Acetic Acid 2-phenylbenzoxazol-5-ylmethyl Ester

HRID 970816

反応式

HRID 970816 の反応式
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:8][C:7]=2[CH:17]=1.[C:18]([O-:21])(=[O:20])[CH3:19].[Cs+]>CN(C=O)C>[C:11]1([C:9]2[O:10][C:6]3[CH:5]=[CH:4][C:3]([CH2:2][O:21][C:18](=[O:20])[CH3:19])=[CH:17][C:7]=3[N:8]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 5152919Cesium acetateHCID 220628305-Bromomethyl-2-phenylbenzoxazole

生成物 1

HCID 23581212Acetic Acid 2-phenylbenzoxazol-5-ylmethyl Ester収率 101.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5-Bromomethyl-2-phenylbenzoxazole 56 (1.0 g, 3.4 mmol) and cesium acetate (1.33 g, 6.94 mmol) were stirred together in DMF(25 ml) under an atmosphere of N2 overnight. The DMF was evaporated under high vacuum and the residue partitioned between ethyl acetate (100 ml) and water (100 ml). The ethyl acetate layer was separated then washed and dried. Evaporation of the solvent yielded 920 mg of acetic acid 2-phenylbenzoxazol-5-ylmethyl ester 57.

後処理

  1. customThe DMF was evaporated under high vacuum
  2. customthe residue partitioned between ethyl acetate (100 ml) and water (100 ml)
  3. customThe ethyl acetate layer was separated
  4. washthen washed
  5. customdried
  6. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-31328c837bef439eb38fa3f8aab89051
出典データセット
uspto-grants-2007_12
特許番号
US07312230B2

関連ノート

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