Aniline → 3-(Phenylsulfamoyl)benzoic acid
反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[C:15]1([NH:14][S:2]([C:5]2[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=2)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1参加物
4
実験手順
3-Chlorosulfonyl-benzoic acid (300 mg, 1.36 mmol), and aniline (0.30 mL, 3.29 mmol) were stirred at room temperature in anhydrous CH2Cl2 (10 mL) overnight under N2. The reaction mixture was concentrated in vacuo. Purification of the residue on IR-120 ion exchange resin column (eluted with methanol) afforded the title compound (380 mg, 100%) as a white solid.
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- customPurification of the residue
- washon IR-120 ion exchange resin column (eluted with methanol)
出典と根拠
- ORDレコード
- ord-15936342bb054069a8bc3805e5cbe2f5
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07312234B2
反応ノート
読み込み中…