Triethylamine → Methanesulfonic acid 4-{[(pyridine-2-carbonyl)-amino]-methyl}-benzyl ester

関与物質

反応手順

Using General Procedure G: Reaction of pyridine-2-carboxylic acid 4-hydroxymethyl-benzylamide (200 mg, 0.83 mmol), Et3N (144 uL, 0.99 mmol), and MsCl (71 uL, 0.91 mmol) for 10 minutes at 0° C. gave the title compound (214 mg, 81%) as a white solid. 1H NMR (300 MHz, CDCl3) δ 2.92 (s, 3H), 4.69 (d, 2H, J=3.3 Hz), 5.23 (s, 2H), 7.41-7.47 (m, 5H), 7.85-7.87 (m, 1H), 8.24 (d, 1H, J=7.8 Hz), 8.50 (br s, 1H), 8.54 (d, 1H, J=3.9 Hz).

情報源と証拠