Ethyl 3-bromoindole-7-carboxylate → 3-Cyano-1H-indole-7-carboxylic acid
反応式
Br[C:2]1[C:10]2[C:5](=[C:6]([C:11]([O:13]CC)=[O:12])[CH:7]=[CH:8][CH:9]=2)[NH:4][CH:3]=1.[C:16]([Cu])#[N:17]>CN1C(=O)CCC1>[C:16]([C:2]1[C:10]2[C:5](=[C:6]([C:11]([OH:13])=[O:12])[CH:7]=[CH:8][CH:9]=2)[NH:4][CH:3]=1)#[N:17]参加物
4
反応条件
- 温度
- 120 °C
実験手順
7 g of ethyl 3-bromoindole-7-carboxylate are dissolved in 70 g of NMP, and 4 g of CuCN are added. The mixture is heated to 100-140° C. with stirring. After 3 hours, the mixture is subjected to conventional work-up, giving 3-cyanoindole-7-carboxylic acid.
出典と根拠
- ORDレコード
- ord-e3bf35874ded474188a9606433d30327
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07312342B2
反応ノート
読み込み中…