Hydrochloric Acid → 2-butylbenzofuran-5-amine Hydrochloride
反応式
[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][C:11]([NH:14]C(=O)C)=[CH:10][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4].[ClH:18]>>[ClH:18].[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4]参加物
3
反応条件
- 温度
- 2.5 °C
実験手順
A mixture of N-(2-butyl-5-benzofuranyl)acetamide [10a] (1.16 g, 5.0 mmol) and 15% hydrochloric acid (10 mL) was stirred overnight under reflux conditions and 2 hours at 0-5° C. The precipitated crystals were filtered off, washed on the filter with cold water and ethyl acetate and dried under reduced pressure at 50° C. (water bath) to a constant weight to give 1.00 g (88.6%) of 2-butyl-5-benzofuranamine hydrochloride [12a] as off-white crystalls with mp 189-192° C. (with decomposition).
後処理
- filtrationThe precipitated crystals were filtered off
- washwashed on the
- filtrationfilter with cold water and ethyl acetate
- dry with materialdried under reduced pressure at 50° C. (water bath) to a constant weight
出典と根拠
- ORDレコード
- ord-31e5a78a2f284e2bbd05a34bddd7aafa
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07312345B2
反応ノート
読み込み中…