Potassium Carbonate → (4-tert-Butyl-phenyl)-[7-(3-chloro-pyridin-2-yl)-2-methoxymethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amine hydrochloride

HRID 971196ノート

反応式

HRID 971196 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:13]3[CH2:24][CH2:23][NH:22][CH2:21][C:14]=3[N:15]=[C:16]([CH2:18][O:19][CH3:20])[N:17]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:25][C:26]1[C:31]([Cl:32])=[CH:30][CH:29]=[CH:28][N:27]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[ClH:25].[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]2[C:13]3[CH2:24][CH2:23][N:22]([C:26]4[C:31]([Cl:32])=[CH:30][CH:29]=[CH:28][N:27]=4)[CH2:21][C:14]=3[N:15]=[C:16]([CH2:18][O:19][CH3:20])[N:17]=2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 169882,3-DichloropyridineHCID 59021476N-(4-tert-butylphenyl)-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4-amine

生成物 1

HCID 69221118(4-tert-Butyl-phenyl)-[7-(3-chloro-pyridin-2-yl)-2-methoxymethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amine hydrochloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound was prepared using the general procedure set forth in Example 3.B. using N-(4-tert-butylphenyl)-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4-amine (0.105 g, 0.32 mmol), 2,3-dichloropyridine (0.071 g, 0.48 mmol), potassium carbonate (0.13 g, 0.96 mmol) and DMF (2 mL) and heating the reaction mixture for 1 h. The title compound was obtained as a light yellow solid after formation and isolation of its hydrochloride salt (15 mg)

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-6cd8b33192904fa0b452ed39c2d589df
出典データセット
uspto-grants-2007_12
特許番号
US07312330B2

反応ノート

読み込み中…