Triethylamine → Z-Gln-Asp(OtBu)-Phe-OCH3

HRID 971542ノート

反応式

HRID 971542 の反応式
[NH2:1][C@H:2]([C:11]([NH:13][C@H:14]([C:22]([O:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12])[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:9])([CH3:8])[CH3:7].Cl.[CH:27]1[CH:32]=[CH:31][C:30]([CH2:33][O:34][C:35]([NH:37][C@H:38]([C:44](OC2C=CC([N+]([O-])=O)=CC=2)=[O:45])[CH2:39][CH2:40][C:41]([NH2:43])=[O:42])=[O:36])=[CH:29][CH:28]=1.C(N(CC)CC)C>CN(C)C=O>[NH:37]([C:35]([O:34][CH2:33][C:30]1[CH:31]=[CH:32][CH:27]=[CH:28][CH:29]=1)=[O:36])[C@H:38]([C:44]([NH:1][C@H:2]([C:11]([NH:13][C@H:14]([C:22]([O:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:12])[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])=[O:45])[CH2:39][CH2:40][C:41](=[O:42])[NH2:43]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 111333Z-Gln-ONpHCID 131711563H-Asp(OtBu)-Phe-OCH3.HCl

生成物 1

HCID 131711562Z-Gln-Asp(OtBu)-Phe-OCH3

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

550 mg of H-Asp(OtBu)-Phe-OCH3.HCl together with 574 mg of Z-Gln-ONP are dissolved in 2.5 ml of absolute N,N-dimethylformamide and stirred with 0.20 ml of triethylamine for 15 hours at 30°-33° C. bath temperature. Thereafter the product is extracted by shaking with a large amount of ethyl acetate as described under 19 and the solution is dried and evaporated.

後処理

  1. extractionThereafter the product is extracted
  2. customthe solution is dried
  3. customevaporated

出典と根拠

ORDレコード
ord-f017a377cb684d529119602f821e0abc
出典データセット
uspto-grants-1979_07
特許番号
US04159981

反応ノート

読み込み中…