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Tetrahydrofuran → (S)-N-Carbobenzyloxy-3-(3,4-diformyloxyphenyl)-2-methylalanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Acetic-formic anhydride | HCID 75269 | — |
| 反応物 | (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid | HCID 18595367 | — |
| 生成物 | (S)-N-Carbobenzyloxy-3-(3,4-diformyloxyphenyl)-2-methylalanine | HCID 54440584 | 100% |
反応手順
A solution of (S)-N-carbobenzyloxy-3-(3,4-dihydroxyphenyl)-2-methylalanine (0.35 g, 1 mmol) and acetic formic anhydride (0.36 g, 4 mmol) in anhydrous tetrahydrofuran (5 ml) is stirred 24 hours at 20°-25° under dry N2. The solvent is evaporated in vacuo and the residue is dried further at 0.1mm/25° for 2 hours. The product (A) (0.4g, 100%) is obtained as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04160712 |
| 出典データセット | uspto-grants-1979_07 |
| ORD ID | ord-3f0910666326437e8a5216fc9950aee0 |
| 出典メモ | uspto-grants-1979_07 |