4-Chloro-8-(trifluoromethyl)quinoline → dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate

HRID 971619

反応式

HRID 971619 の反応式
[C:1]([O:10][CH2:11][P:12]([CH3:15])([CH3:14])=[O:13])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].Cl[C:17]1[C:26]2[C:21](=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:24][CH:25]=2)[N:20]=[CH:19][CH:18]=1>C(O)(C)C.Cl>[F:30][C:27]([F:28])([F:29])[C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:21]=1[N:20]=[CH:19][CH:18]=[C:17]2[NH:4][C:3]1[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:1]([O:10][CH2:11][P:12]([CH3:15])([CH3:14])=[O:13])=[O:9]

参加物

5

反応物 2

HCID 902624-Chloro-8-(trifluoromethyl)quinolineHCID 12669155Dimethylphosphinylmethyl anthranilate

生成物 1

HCID 12669152dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 3776Isopropanol溶媒

実験手順

4.6 grams (0.02 mol) of dimethylphosphinylmethyl anthranilate and 4.6 grams (0.02 mol) of 4-chloro-8-trifluoromethylquinoline are kept at 80° C. for about three and a half hours in 15 ml of isopropanol and 2.3 ml of concentrated aqueous hydrochloric acid. After removing the solvents and excess hydrochloric acid, the free base of the ester is liberated at 0° C. The dimethylphosphinyl-methyl N-(8-trifluoromethyl-4-quinolyl)-anthranilate obtained is identical to that prepared in Example 2a). Yield: 7.6 grams (90% of theory).

後処理

  1. customAfter removing the solvents and excess hydrochloric acid
  2. customis liberated at 0° C

出典と根拠

ORDレコード
ord-b80cd8f233344c97a8eee27789d951d4
出典データセット
uspto-grants-1979_07
特許番号
US04160828

関連ノート

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