化工社化工社 化学情報印刷レポート · 研究参考用
1,2,4-Trichlorobenzene → 3,6-Dichlorosalicylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2,4-Trichlorobenzene | HCID 13 | — |
| 反応物 | 2,5-Dichlorophenol | HCID 66 | — |
| 反応物 | Carbon Dioxide | HCID 280 | — |
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Dicamba | HCID 3030 | — |
| 反応物 | 1,2,3-Trichlorobenzene | HCID 6895 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3,6-Dichlorosalicylic acid | HCID 18844 | — |
反応手順
The compound 2-methoxy-3,6-dichlorobenzoic acid is a valuable herbicide and is used in commerce for the control of a variety of undesirable vegetation. The prior art discloses in U.S. Pat. No. 3,013,054 that the 2-methoxy-3,6-dichlorobenzoic acid is prepared from 1,2,4-trichlorobenzene in a three-stage process. The trichlorobenzene is first converted to 2,5-dichlorophenol with methanol and sodium hydroxide. The phenol is then treated with carbon dioxide under pressure to yield 2-hydroxy-3,6-dichlorobenzoic acid. The hydroxy acid is then methylated with dimethyl sulfate or methyl chloride to yield the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04161611 |
| 出典データセット | uspto-grants-1979_07 |
| ORD ID | ord-46bcb6126a8742e8990ca55f52b9e759 |
| 出典メモ | uspto-grants-1979_07 |