化工社化工社 化学情報印刷レポート · 研究参考用
Benzene → Bicyclo(3.1.0)hexan-2-one, 5-(1-methylethyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sulfoxonium, trimethyl-, iodide (1:1) | HCID 74498 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Bicyclo(3.1.0)hexan-2-one, 5-(1-methylethyl)- | HCID 92784 | 42% |
反応手順
25 ml of DMSO, 35 ml of benzene, 25 ml of isopropyl alcohol, 3.1 g (25 mM) of CP, 2.4 g (30 mM) of 50% aqueous sodium hydroxide and 5 ml of water were added to 6.9 g (31.25 mM) of trimethylsulfoxonium iodide and the reaction was carried out at room temperature for 5 hours. Then, the treatments were carried out as described in Example 8. 2.6 g (76% yield) of crude product were produced, from which1.45 g (42 % yield) of sabina ketone were obtained by distillation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04162258 |
| 出典データセット | uspto-grants-1979_07 |
| ORD ID | ord-f188c799d94b41fb894a66beaaba8e2c |
| 出典メモ | uspto-grants-1979_07 |