Ammonia → 1-Pyrrolidineacetamide, N-(2-amino-2-oxoethyl)-2-oxo-
反応式
C(O[C:4](=[O:16])[CH2:5][NH:6][C:7](=[O:15])[CH2:8][N:9]1[CH2:13][CH2:12][CH2:11][C:10]1=[O:14])C.[NH3:17]>CO>[O:14]=[C:10]1[CH2:11][CH2:12][CH2:13][N:9]1[CH2:8][C:7]([NH:6][CH2:5][C:4]([NH2:17])=[O:16])=[O:15]参加物
4
実験手順
17.1 g (0.075 mole) of N-(2-oxo-1-pyrrolidineacetyl)-glycine ethyl ester are dissolved in 350 ml of methanol. The solution is saturated with a current of ammonia (about 2 hours), stirring is maintained for 3 hours at ambient temperature. After the reaction mixture has been evaporated to dryness in vacuo, the residue crystallizes quickly, 14.9 g of 2-(2-oxo-1pyrrolidineacetamido)-acetamide being obtained (yield: 100% of theory); M.P. 147°-148° C.
後処理
- customAfter the reaction mixture has been evaporated to dryness in vacuo
- customthe residue crystallizes quickly
出典と根拠
- ORDレコード
- ord-8b2909cb751b4a7c9c3682a1813fa0f4
- 出典データセット
- uspto-grants-1979_07
- 特許番号
- US04162325
反応ノート
読み込み中…