Methylamine → HCID 15308078、化合物

反応式

[CH3:1][NH2:2].C(O[C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16])C>>[CH3:1][NH:2][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16]

参加物

反応物 2

HCID 6329Methylamine

HCID 14715871HCID 14715871、化合物

生成物 1

HCID 15308078HCID 15308078、化合物収率 92%

実験手順

31 g (1 mole) of methylamine are added to 18.24 g (0.08 mole) of N-(2-oxo-1-pyrrolidineacetyl)-glycine ethyl ester and the reaction mixture is kept at -20° C. for 8 hours, while stirring. It is then evaporated and the residue is recrystallized from absolute ethanol, 15.7 g. of N-methyl-2-(2-oxo-1-pyrrolidineacetamido)-acetamide being obtained (yield: 92% of theory); M.P. 139°-140° C.

後処理

customIt is then evaporated
customthe residue is recrystallized from absolute ethanol, 15.7 g

出典と根拠

ORDレコード: ord-e8c597f628004be8bf564717e2eae122
出典データセット: uspto-grants-1979_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04162325

反応ノート

読み込み中…

参加物